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🧠 Fentanyl's power and its danger come from the exact same place — the mu-opioid receptor. Your brain has a built-in pain volume knob: pain signals travel up to the brain (ascending pathway), and the brain fires signals back down to dial the pain down (descending pathway). Fentanyl hijacks this system and cranks it to an extreme. 🎚️ Mu-opioid receptors explain everything: 🧠 Brain — reduces pain perception 🔬 Spinal cord — blocks pain signal transmission 🚽 Digestive tract — slows gut motility
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