From the departments of Pediatrics and Medicine, University of Maryland School of Medicine. Aided by grants from the National Science Foundation and the Playtex Park Foundation. We are indebted to ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

A CSF leak within the spinal column is the most common identifiable cause of spontaneous intracranial hypotension. 3 The mechanism underlying headache and neurologic manifestations is presumed to ...

This article reviews the progress made during the past decade in elucidating the pathophysiological mechanisms of hereditary angioedema and the subsequent development of targeted treatments for ...

Schistosomiasis is a parasitic neglected tropical disease that is estimated to currently infect more than 140 million persons. 1,2 Ninety percent of the disease burden is in sub-Saharan Africa ...

Attention deficit–hyperactivity disorder (ADHD) is characterized by hyperactivity and impulsivity, by inattention, or by a combination of hyperactivity, impulsivity, and inattention that is ...

In 1928, Sir Alexander Fleming discovered that the active component of a penicillium fungus had the capacity to kill bacteria in a petri dish, and he named it penicillin. In 1945, Fleming, Florey ...

Dupilumab (interleukin-4Rα; antibody binds to interleukin-4Rα, inhibiting interleukin-4 and interleukin-13 signaling in hematopoietic cells [e.g., B cells, CD4+ helper T cells, and eosinophils ...

We and others identified retinoblastoma features that suggested that the tumors originate in long- and medium-wavelength cone precursors, and we discovered features of these cone precursors that ...

Squamous non–small-cell lung cancer (NSCLC) accounts for approximately 20 to 30% of all lung cancers and is associated with shorter survival than is nonsquamous NSCLC. 1-4 Historically, the lack ...

Hormone absence or inactivity is common in congenital disease, but hormone antagonism remains controversial. Here, we characterize two novel homozygous leptin variants that yielded antagonistic ...

Shown are the phases of rupture and healing of an atherosclerotic plaque. The cross-section of a plaque in Panel A shows a central core containing lipids and necrotic debris (yellow) and ...