Thorax

Predictive capacity of paediatric nasal epithelial cells in sequential CFTR modulator therapy

Background CFTR modulators have transformed cystic fibrosis (CF) treatment, but individual responses vary even among patients with identical CFTR genotypes. This underscores the need for predictive ...
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Shape-sensing robotic-assisted bronchoscopy with integrated mobile cone-beam CT for small nodules: results from the prospective multicentre CONFIRM study

Background The use of 3D imaging with navigation bronchoscopy has increased with the introduction of mobile cone-beam CT (mCBCT). Shape-sensing robotic-assisted bronchoscopy (ssRAB) integrated with ...
Thorax

Blood eosinophil-guided systemic corticosteroid duration in adults hospitalised for asthma exacerbation: a randomised, controlled, open-label, non-inferiority trial

Objective Systemic corticosteroids for 5–7 days are standard care for asthma exacerbations, but the optimal duration and ...
Thorax

Maternal eating disorders and respiratory outcomes in childhood: findings from the EU Child Cohort Network

Background While maternal depression and anxiety have been linked to adverse childhood respiratory outcomes, the role of ...
Thorax

Multidisciplinary, non-pharmacological breathlessness intervention service for patients with moderately severe to severe COPD: a randomised controlled trial

Breathlessness intervention services (BIS), which coach patients to self-manage breathlessness using non-pharmacological ...
Thorax

Disproportionate impairment in diffusing capacity predicts pulmonary hypertension with an elevated pulmonary vascular resistance in COPD

Background Current guidelines for the evaluation of chronic obstructive pulmonary disease (COPD) do not recommend screening ...
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Incidence and recognition of acute respiratory distress syndrome in a UK intensive care unit

Correspondence to Dr Charlotte Summers, Division of Anaesthesia, Department of Medicine, Box 93, Level 4, Addenbrooke's Hospital, CUHNHSFT, Hills Road, Cambridge CB2 OQQ, UK; ...
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Coronary artery calcification is increased in patients with COPD and associated with increased morbidity and mortality

12 Department of Respiratory Medicine, Odense University & University of Southern Denmark, Denmark/University of Manchester, Academic Health Science Centre, Manchester, UK 13 Department of Respiratory ...
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Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality

3 Pulmonary Division, Jewish General Hospital, McGill University, Montreal, Canada Correspondence to Professor Samy Suissa, Centre for Clinical Epidemiology, Jewish General Hospital, 3755 Cote ...
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Churg-Strauss syndrome associated with montelukast therapy

Churg-Strauss syndrome is a rare form of eosinophilic vasculitis associated with asthma. There have been several recent case reports of the condition in association with leukotriene antagonists and it ...
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The dynamics of the pulmonary microbiome during mechanical ventilation in the intensive care unit and the association with occurrence of pneumonia

Rationale Ventilator-associated pneumonia (VAP) is the most common nosocomial infections in patients admitted to the ICU. The adapted island model predicts several changes in the respiratory ...
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Aetiological role of viral and bacterial infections in acute adult lower respiratory tract infection (LRTI) in primary care

2 Department of Thoracic Medicine, Royal Free and University College Medical School, University College London, UK 3 Centre for Medical Microbiology, Royal Free and University College Medical School, ...