However Sunday night, the 272nd and final game of the regular season, will have winner-take-all stakes as the archrival Pittsburgh Steelers and Baltimore Ravens vie for the AFC North title in the latest installment of their border way. The loser goes gets nothing.

The final weekend of the NFL regular season is upon us, and there are quite a few games that will determine postseason bids and seeding.

Welcome to the final week of the 2025 NFL season! Just 16 games seperate us from the playoffs, so let's enjoy the last full slate of games until the 2026 season

Cowboys (-3.5) at Giants: The Raiders understood the assignment in their Week 17 Tank Bowl loss against the Giants. This dumbass Giants team did not. The Giants are going to try to win this game too, but so will Dak Prescott, who has a chance to lead the NFL in passing yards.

Picking the Ravens over the Steelers is almost too easy. We also like the Seahawks over the 49ers and Bucs over Panthers in critical games.

Without a clear-cut favorite from the top seeds to the final wild-card teams, the playoffs figure to be as difficult to predict as all the surprises that led up to a fresh field of 14 teams. Here's breaking down our best bets to survive and advance in another round of picks and predictions against the spread: The 49ers ' offense will do its best to make up for an injury-riddled defense.

Despite its stellar record, Denver is only 6-9-1 against the spread. Los Angeles is 8-7-1 ATS but had four straight covers before losing to the Texans at home in Week 17. The Chargers are 6-9-1 to the Over while the Broncos are 7-9 to the Over.