It's another intriguing slate of NFL contests in Week 6 as we approach the middle of the season. Here are the picks against the spread from our expert staff. Opening Line: Eagles -7 Grimes: Eagles -7.5 A perfect get-right game for the Eagles, unfortunately.

And then there were none. Entering Week 5, there were just two undefeated teams remaining in the NFL, but both fell at home.

The San Francisco 49ers will take on the Tampa Bay Buccaneers this week. Here's what the experts think will happen on Sunday at Raymond James Stadium

You can also see the model's best bets for every Week 6 NFL game, including Cowboys vs. Panthers, Seahawks vs. Jaguars and Chiefs vs. Lions. Finally, SportsLine expert RJ White, who is 57-35 (+2470) over his last 92 NFL picks, has locked in multiple Week 6 ...

"NFL Fantasy Live" anchor Patrick Claybon, fantasy analyst Adam Rank, and analytics expert Cynthia Frelund discusses which players to target on the waiver wire after Week 9 of the 2025 NFL season.

“Denver beat Dallas for the seventh straight time Sunday. The last Cowboys team to beat the Broncos was coached by Barry Switzer and got 114 rushing yards from Emmitt Smith. Bo Nix threw four touchdown passes and J.K. Dobbins rushed for 111 to keep the streak alive,” Josh Kendall and Chad Graff write. See the full rankings.

Up next the Patriots are on the road to Tampa Bay to face the 6-2 Buccaneers, followed by a Thursday Night game vs. the Jets at home. The Baker Mayfield-led Bucs are coming off their bye and it will be a tough matchup.