Adhesion G protein-coupled receptors have a large extracellular region (shown in green and orange) that extends into space outside the cell. Almost 35% of drugs approved by the Food and Drug ...

One of the most exciting advances in cancer treatments in the past decade is the development of T cell immunotherapies, in which a patient's own immune system is trained to recognize and attack ...

Among patients with mycosis fungoides (MF) and Sézary syndrome (SS), the T-cell receptor (TCR) clonal Vb20 segment was significantly associated with advanced-stage disease, folliculotropism with ...

A research team led by Prof. Zhou Rongbin from the University of Science and Technology of China (USTC) discovered the mechanism by which lysophosphatidylserine (LysoPS) inhibits the anti-tumor ...

Scientists have discovered that T cell receptors activate through a hidden spring-like motion that had never been seen before. This breakthrough may help explain why immunotherapy works for some ...

Researchers found that mice lacking membrane ERα signaling in osteoblast lineage cells had significantly lower cortical bone mass, highlighting the pathway’s critical role in maintaining the strength ...