Signal transduction by members of the Hedgehog (Hh) family of molecules is essential during development. As morphogens, Hh proteins are secreted from localized sources to induce distinct concentration ...
Sonic hedgehog (Shh) signalling, mediated by Patched and Smoothened, functions as a morphogen or a mitogen during many developmental processes 1,2,3. Mutations in the Shh pathway components lead to ...
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