Schematic diagram of the IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages. IRs, inhibitory receptors (IRs); ICIs, immune checkpoint inhibitors; IL-6, interleukin-6; ALT, alanine ...
Schematic showing IL-6-induced STAT3-to-PI3K signaling switch in colorectal cancer stem cells, driving ZEB1-dependent PD-L1 expression and immune evasion. A landmark study published in Science ...
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