The puzzle seems impossible: take a three-billion-letter code and predict what happens if you swap a single letter. The code we’re talking about—the human genome—stores most of its instructions in ...

Around 98.5% of human DNA is non-coding, meaning it doesn’t get copied to make proteins. A new study has connected many of these non-coding regions to the genes they affect and laid out guidelines for ...

Sections of DNA once dismissed as dormant and useless could in fact be recruited to fight certain types of drug-resistant blood cancers, new research has revealed. Known as 'junk' DNA, these bits of ...

Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.

Many sections of the non-coding region of the human genome play a key role in regulating gene activity. But the relationship between non-coding mutations and cancer risk has been a mystery. New ...

What keeps our cells the right size? Scientists have long puzzled over this fundamental question, since cells that are too large or too small are linked to many diseases. Until now, the genetic basis ...

In a new study, stem cell scientists at the Lund University, Sweden, explore the role of non-coding regions of the genome—previously deemed to be functionless “junk” DNA—and find humans and ...

Researchers at the Icahn School of Medicine at Mount Sinai and others have identified a neurodevelopmental disorder, caused by mutations in a single gene, that affects tens of thousands of people ...

Scientists have found that non-coding 'junk' DNA, far from being harmless and inert, could potentially contribute to the development of cancer. Their study has shown how non-coding DNA can get in the ...

New research indicates faults in repairing DNA breaks that are caused by oxidative stress in the noncoding parts of the genome are directly involved in the development of neurological diseases. The ...

Researchers at the Icahn School of Medicine at Mount Sinai, and collaborators at the University of Bristol, KU Leuven, and the NIHR BioResource, have identified a neurodevelopmental disorder, caused ...