Must-win AFC North and NFC South showdowns? No. 1 seeds on the line? We have picks, predictions, stats and what's at stake for every Week 18 game.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 18 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Will Myles Garrett break the NFL's single-season sacks record? Can Derrick Henry duplicate last week's performance in the Ravens' biggest game of the year? Our analysts provide bold predictions for Week 18 of the 2025 NFL season.