Preliminary data from an ongoing phase IIb study of no carrier added 131I-iobenguane (nca-MIBG) in patients with malignant pheochromocytoma (Pheo). Absence of human papilomavirus (HPV) in tissues ...

Two separate studies report a range of mutations involved in the disease and one discovers an inhibitor. New evidence on the molecular mechanisms that underlie aberrant NF-kB activity in multiple ...

Primary resistances to EGFR inhibitors (EGFRi) in HPV-positive and -negative oropharyngeal squamous cell carcinoma (OSCC). Background: Our previous study on prostate cancer (PCa) tissues shows that ...

Endocrine therapy typically slows cell cycle progression by reducing cyclin D1, which partners with CDK4/6 to promote cell ...

The diagram depicts negative feedback mechanisms via IκB proteins and A20 in the canonical pathway, and IKKα onto NIK in the non-canonical pathway. There are cross-talk mechanisms such as NIK ...

Sterile alpha motif and HD-domain–containing protein 1 (SAMHD1) blocks replication of retroviruses and certain DNA viruses by reducing the intracellular dNTP pool. SAMHD1 has been suggested to ...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV-2 has a single-stranded RNA genome encoding both ...

The therapeutic effects of cannabinoids have been well-documented, but the effect of cannabinoids on the immune system is still not explored to a great extent. In a recent study, the researchers ...

Mastitis is a disease involved in inflammation of breast which affects human and animals. Wogonin is one bioactive compound from many Chinese herbal medicines, which have multiple properties, ...

Bruce D. Freedman, VMD, PhD, Associate Professor, School of Veterinary Medicine, University of Pennsylvania Uri Hershberg, PhD, Associate Professor, School of Biomedical Engineering, Science and ...