Background Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with limited therapeutic options. Despite ...
Macrophages are part of the immune system's frontline; they attack and eat invaders to protect surrounding cells. They, along with other cells, maintain intracellular conditions through macroautophagy ...
The understanding of how macrophages regulate their response to toxic particles via two independent pathways could uncover therapeutic opportunities to quell inflammation BIRMINGHAM, Ala. – Human ...
New research reveals that aging immune cells can become locked in a self-sustaining inflammatory state, worsening the body’s ...
Schematic diagram of the IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages. IRs, inhibitory receptors (IRs); ICIs, immune checkpoint inhibitors; IL-6, interleukin-6; ALT, alanine ...
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Immune cell energy metabolism shapes the progression of atherosclerosis
Two complementary studies reveal how an insufficient supply of energy in macrophages, key immune cells in artery walls, ...
Idiopathic pulmonary fibrosis (IPF) is a chronic disease in which healthy lung tissue is gradually replaced by scar tissue. While the early events that initiate this change are poorly understood, ...
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