Particular major histocompatibility complex (MHC) class II alleles clearly contribute to T cell-mediated autoimmune type 1 diabetes (T1D) in both humans and nonobese diabetic (NOD) mice. However, ...
In a recent article posted to the bioRxiv* preprint server, researchers demonstrated the sarbecovirus open reading frame 7a (ORF7a)-induced hindrance of the antigen presentation by the major ...
HLA-G is a nonclassical MHC class I (MHCI) molecule that can suppress a wide range of immune responses in the maternal-fetal interface. The human inhibitory immune receptors leukocyte Iglike receptor ...
Clinical utilization of precision oncology decision support for genomically-informed cancer therapy. PD-1, PD-L1, and B7-H3 expression in Human Immunodeficiency Virus (HIV) infected patients with ...
Human leukocyte antigen (HLA) typing is important in organ transplantation protocols, as they determine the likelihood of rejection. The HLA system is little understood, however. In simple terms, the ...
Trading treatment toxicity for survival in locally advanced non-small cell lung cancer. Seventeen HLA-B7-negative patients were treated with intralesional injection of Allovectin-7. Twelve patients ...
Researchers harnessed a natural system, the major histocompatibility complexes (MHCs), to take targeted drugs -- only when attached to their protein targets inside cancer cells -- and display them on ...
AUSTIN, Texas--(BUSINESS WIRE)--MHC Biologics, LLC, an emerging biotechnology company, has developed a unique and proprietary portfolio of breakthrough technologies that can be used in the development ...
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