Of the more than 3,000 variants that have been identified in the NF1 gene, only a handful of specific variants can be correlated to certain NF1 symptoms. In this post, I’ll discuss the major known ...

The relationship between RNA sequences and their resultant structures is central to understanding evolutionary processes and molecular robustness. Genotype–phenotype mapping studies reveal how subtle ...

In this interview conducted at Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to this year’s recipient of the Pittsburgh Analytical Chemistry Award, Neil Kelleher. My name is Neil Kelleher, and ...

A phenotype refers to the observable characteristics or traits of an organism that result from the interaction between its genotype (genetic makeup) and the environment. It encompasses an organism's ...

Humans have approximately 20,000 human protein-coding genes, and the proteins they express span a concentration range of ~12 logs. Yet only 0.1% of proteins contribute to 99% of the total plasma ...

This seminar is open to the research community. Tuesday, December 5, 2023 - 11:00 a.m. to 12:00 p.m.

The genotype of an organism is inherited from its parents through the process of reproduction. During sexual reproduction, each parent contributes half of the genetic material to the offspring, ...

Clinical and Molecular Evolution of an ALK-Driven Infant-Type Hemispheric Glioma Treated Sequentially With Second- and Third-Generation Anaplastic Lymphoma Kinase Inhibitors The following represents ...

Researchers found that paired pathogenic variants can restore protein function rather than make it worse. This phenomenon ...