Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

Understanding how a potential drug is metabolised in the liver is a critical first step in early-stage drug development - but ...

Researchers at The University of Tokyo developed TECHNO, a two-step genome editing strategy that replaces entire mouse loci with human genomic DNA. The method integrates fragments over 200 kbp.

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

It often involves the introduction of genetic material into a person’s cells to replace a defective or missing gene. Although early attempts at gene therapy have been effective in achieving the ...

Mice and newts were applied to the one-step Cre-loxP organism creation technology by TAx9. In this study, the researchers succeeded in synthesizing a Cre-loxP integrated vector by placing a short DNA ...

A new study led by researchers at UTHealth Houston investigated both gene expression and regulation at single cell levels to ...

What if you could flip a genetic switch to silence a gene, then turn it back on with a simple drug? For researchers, gene-switch tools offer that kind of control—and a new system called Cyclone may ...

Our brain is arguably the organ that most distinguishes humans from other primates. Its exceptional size, complexity and capabilities far exceed those of any other species on Earth. Yet humans share ...