DNA is the blueprint of life. Genes encode proteins and serve as the body's basic components. However, building a functioning ...

Researchers at the Weill Institute for Cell and Molecular Biology have uncovered new evidence that two major types of gene-controlling DNA sequences, promoters and enhancers, operate with a shared ...

Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene ...

Researchers developed e2MPRA, a high-throughput technique that simultaneously measures cis-regulatory element activity and ...

Gene regulation is the process by which cells control the expression of their genes, determining when, where, and to what extent each gene is expressed. It is a fundamental mechanism that allows cells ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

Investigators at Weill Cornell Medicine have developed a versatile and non-toxic technology for controlling the activity of any gene in a cell. Such "gene-switch" tools allow scientists to "turn on" ...

Human DNA constantly refolds in 3D space, and these looping dynamics regulate gene expression and cell identity.

Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

Less than 2% of the genome codes for proteins; the rest, once called 'junk DNA', contains regulatory elements. Researchers ...