The advent of highly efficient genome engineering technologies that enable site-specific manipulation of chromosomes offers exciting opportunities for industrial strain engineering. However, the ...

Ten years ago, Stuart L. Schreiber of Harvard University and coworkers reported a technique for making natural-product-like compound collections that featured an unprecedented diversity of structures.

Understanding the function of stochasticity in biological systems has been a long-standing challenge 1,2,3. Two main principles have been recognized. First, stochastic algorithms allow simpler genetic ...

Researchers have illuminated how competition between proteins enhances combinatorial diversity during ubiquitination -- the process that marks proteins for destruction. Dieter Wolf, M.D., and ...

The specificity of interactions between neurons is believed to be mediated by diverse cell adhesion molecules, including members of the cadherin superfamily. Whereas mechanisms of classical cadherin ...