A major problem in solid-phase peptide synthesis (SPPS) is aggregation and poor solvation leading to incomplete deprotection and/or coupling steps, resulting in low crude purity peptides. 1 This ...

Peptides are powerful but fragile molecules whose stability depends on meticulous storage and handling. Heat, moisture, light, and pH shifts can quickly degrade their structure and reduce biological ...

Proteins carry out exceptionally diverse molecular functions—even though they are all built on an unvarying polyamide backbone. How much more chemical diversity might be unlocked by editing that ...

Pharmaceutical scientists at the National University of Singapore (NUS) have developed a novel chemical reaction that enables the precise functionalization of peptides and proteins. This approach ...