Starting with Sunday’s road battle against the Buffalo Bills, each of the Chiefs’ next four games features a matchup against one of the NFL’s top four leading rushers. First up: Buffalo’s James Cook, who is coming off a 216-yard performance on the ...

The Chiefs-Bills game is the biggest on the NFL's regular-season schedule but the league has a reason for not having it in prime time.

Welcome to Round 10 of Patrick Mahomes vs. Josh Allen, or more accurately, the Kansas City Chiefs (5-3) vs. Buffalo Bills (5-2) on Sunday (4:25 p.m. ET, CBS). Both teams have finished atop their respective divisions for the past five seasons and have met in each regular season since 2020 -- plus four postseason games in that span.

The Bills have the Chiefs' number in regular-season play. They are 5-1 against Kansas City in regular-season meetings since 2017 and won each of the last four matchups. It is when the stakes are at their highest that the Chiefs take control. They won each of the four playoff showdowns since Mahomes and Allen joined their respective teams.

The Chiefs and Bills will meet at Highmark Stadium in Orchard Park, New York, on Sunday, Nov. 2, 2025. Kickoff time is 3:25 p.m. (Central Time). The game will be televised by CBS. In Kansas City, it will be on KCTV (Channel 5). In Wichita, it’s on KWCH (Channel 12)

Chiefs running back Isiah Pacheco has officially been ruled out for Sunday’s game against the Bills.

Kansas City Chiefs coach Andy Reid confirmed what many observers and fans already suspected, which was that running back Isiah Pacheco will miss Sunday’s AFC title game rematch against the Buffalo Bills due to a knee injury.