Israel’s attacks on Iran have scrambled air travel in the Middle East – again. Iran, Israel, Iraq and Jordan all closed their airspace to civilian aircraft as Israel launched waves of aerial attacks against Iran,

The attacks marked the most significant blow to Iran’s military leadership in recent history, with the country losing its two top commanders — Bagheri and Major General Hossein Salami, commander of the elite Islamic Revolutionary Guard Corps — in a single day.

The US State and Defense departments on Wednesday made efforts to arrange the departure of non-essential personnel from locations around the Middle East, according to US officials and sources familiar with the efforts.